Cancer is in constant combat with the body. Hostile cells can trigger an intricate network of interactions alerting the #immunesystem . But many #cancercells fly under the #radar . Now advanced #sequencing#techniques are helping #researchers unravel these complex interactions with the potential to boost the immune system and provide #life -saving #treatments .
The cancer cells have #mutations that cause them to relentlessly divide. But these mutations can be different between patients and even between neighboring cancer cells and not all mutations are created equal. To come up with treatments, researchers first need to know which mutations will sound their immune systems alarm. #Cancercell mutations can lead to abnormal proteins.
In cells proteins are constantly broken up into peptides. Foreign peptides can only be spotted if they're displayed on the surface of a cell. The immune system uses #majorhistocompatibilitycomplex or MHC #molecules to bind to the peptides and carry them to the cell surface. But MHC is vary a lot between patients and can't always bind to the mutant peptides. Mutant peptides that can trigger an #immuneresponse and are specific to the tumor are called #neoantigens and to find out which mutations lead to new your antigens researchers can use sequencing. Comparing the DNA from cancer cells with healthy cells shows which mutations the cancer has, and sequencing RNA can then show which abnormal proteins might be produced. Sequencing can also reveal what that MHC molecules will look like and together with the mutant protein sequences this can predict which new #antigens cells will display.
But this is only half the story because even when new antigen MHC complexes are produced the immune system might still miss them and fail to respond to the threat. T-cells are the body's way of spotting foreign molecules. .. continue in the comment section
nature.com #cancerimmunotherapy#cancerimmunology#immunotherapy#genomics#proteomics#olcology#Cancerresearch#ciencia#nanobioart ...
The newest edition of the NCC LIFT Newsletter is here! Learn about federal legislation currently being debated, explore the new NCC State Regulation tracking reports, and more. Link in bio for the newsletter. #genetics#genomics#healthpolicy ...
What comes to your mind when you hear the words Gene Editing?
Students of second-year Medical Genomics asked this question around the city. Deciding to bust myths, they set out to debunk notions set by mainstream media and Hollywood blockbusters.
Learn more about gene editing, CRISPR, and its role in the field of genetics and innovation. Watch their episode to understand the norms and facts surrounding gene editing: http://bit.ly/MythDecoders_GeneEditing
Have you heard of any CRISPR myths? Share your thoughts with us in the comments below. ...